- Researchers have found that men seem to bemore vulnerable to COVID-19 than women. It suggested the reason might be related to the concentration of the enzyme Angiotensin-Converting Enzyme 2 (ACE2) in the blood of men and women.
- TheACE2 enzyme in blood responds to the novel coronavirus and enables it to infect the human cell.
- ACE2 is also a receptor present on the surface of healthy cells. TheSARS-CoV-2 virus uses this receptor to enter inside cells. ACE2 receptors are present in abundance in the lungs, heart, kidneys, and testes.
- The study found men have higher concentrations of ACE2 in their blood than women. It also showed heart failure patients who are taking a certain class of drugs, called RAAS inhibitors, did not have higher concentrations of ACE2 in their blood. But, some studies suggested RAAS inhibitors might increase ACE2 concentrations in blood plasma.