General Science
BioEmu
▪ BioEmu is a deep learning system developed by Microsoft, Rice University, and Freie Universität.
▪ It models protein flexibility at high resolution and large scale, unlike traditional methods.
▪ AlphaFold predicts a single stable structure of a protein.
▪ BioEmu predicts the entire range of conformations a protein can adopt — called the equilibrium ensemble.
▪ Protein movement is essential for function — such as enzyme activation, cell signalling, and drug binding.
▪ BioEmu reveals dynamic shapes, like cryptic pockets (temporary drug binding sites).
