Latest inventions in science and technology BIRSA 101 Gene Therapy India has launched its first indigenous CRISPR-based gene therapy for Sickle Cell Disease, named BIRSA 101, marking a major milestone in affordable genomic medicine. The therapy is named "BIRSA 101", dedicated to the tribal freedom fighter Bhagwan Birsa Munda, whose 150th anniversary was recently observed. Developed by CSIR–Institute of Genomics & Integrative Biology (IGIB) BIRSA 101 uses CRISPR technology like “precise genetic surgery” to edit defective genes inside the patient’s cells. It corrects the mutation responsible for producing sickle-shaped red blood cells, thereby enabling normal haemoglobin production. Once edited, the corrected stem cells are infused back into the patient, offering a potential one-time, and lifelong cure. Key Features: Fully indigenous CRISPR platform (enFnCas9) engineered by IGIB. Low-cost alternative to global therapies costing crores. Developed under India’s Atmanirbhar Bharat push for medical self-reliance. Backed by a public–private partnership ensuring scalability, safety, and regulatory readiness.
