Latest inventions in science and technology CAR-T Cell Therapy Context: Researchers have developed a promising new CAR T cell therapy for rare solid tumours, including alveolar soft part sarcoma (ASPS) and certain kidney cancers. About CAR-T Cell Therapy CAR-T (Chimeric Antigen Receptor T-cell) therapy is a type of immunotherapy that uses a patient's own T cells to destroy cancer cells. Approved for treating blood cancers, mainly leukaemia and lymphoma. Known as "living drugs" because genetically modified T cells remain active inside the body. Procedure T Cell Collection: T cells are collected from the patient's blood through apheresis. Genetic Engineering: T cells are modified to express Chimeric Antigen Receptors (CARs). Target Recognition: CARs enable T cells to identify specific antigens on cancer cells. Cell Expansion: Modified CAR-T cells are multiplied in the laboratory. Reinfusion: Engineered cells are infused back into the patient to attack cancer cells. Development in India NexCAR19 is India's first indigenous CAR-T cell therapy. Developed by ImmunoACT, IIT Bombay, and Tata Memorial Hospital. Approved by the Central Drugs Standard Control Organisation (CDSCO) in October 2023. Approved for treating selected B-cell blood cancers. NexCAR19 is the first CAR-T therapy in India to receive CDSCO approval for commercial use.
