An enzyme that goes by the name SIRTI is known to be associated with regulation of metabolic activities and also ageing and hence has become a target of therapeutics. A study by researchers from Tata Institute of Fundamental Research, Mumbai (TIFR) shows that glucose controls the function of SIRTI directly. A shortage or absence of this control can lead to a diabetic-like state, while excess feeding and sustained low levels of SIRTI can lead to obesity and enhanced ageing. The study was published in the Proceedings of the National Academy of Sciences.
